Neurotoxins

BOTOX • DAXXIFY • JEUVEAU

Neurotoxin injections are a powerful cosmetic solution for getting rid of wrinkles, sagging skin, and premature aging signs. Besides being the go-to anti-age treatment, they are also used for jawline contouring, treating muscle stiffness, and reducing excessive sweating.

You may be familiar with Botox, but there are other neurotoxins available on the market that are equally effective for wrinkles.

Read the following guide on neurotoxin injections to learn about the procedure, different types, and expected outcomes.

What Are Neurotoxin Injections?

Neurotoxin injections, available under the brand names Botox, Jeuveau, and Daxxify, contain small, diluted amounts of botulinum toxin, a neurotoxin produced by the bacterium Clostridium botulinum. Once injected into the muscle, the toxin blocks nerve signals that travel to the muscles, causing a reduction in muscle activity and smoothing the skin.

Types of Neurotoxin Injections

Botox, Jeuveau, and Daxxify are all different trade names for injectables with the same active ingredient. The differences between them lie in their molecular structures and the parts of the nerve they attach to.

This means that dosages are not equivalent across different products – so one unit of Botox is not the same as one unit of Dysport. Besides, the duration of the effects can differ across products, as well as the body’s immune response.

Botox

Botox injections don't need any special introduction. It has become so popular and widespread across the globe that people use the word “Botox” to talk about other brands on the market.

Common Botox treatment areas include frown lines (between the eyebrows), forehead lines, wrinkles around the eyes (crow’s feet), and chin wrinkles.

Lines under the eye (tear through), lipstick lines, and neck wrinkles can be better treated with dermal fillers, either alone or combined with Botox.

Daxxify

Formerly known as Daxi, this injectable is the newest addition to the neurotoxin family, approved in September 2022. It contains a purified protein of botulinum toxin A and a peptide excipient that keeps the active ingredient stuck to the nerve terminal. The peptide works as a stabilizer, prolonging the wrinkle-relaxing effect.Its innovative, peptide-powered formula is FDA-approved for glabellar lines.

THE DAXXIFY® DIFFERENCE

Results from frown line treatments

DAXXIFY® is different from conventional frown line treatments because it is the only treatment powered by a peptide. DAXXIFY® does not contain human or animal byproducts, like other frown line treatments. If you are looking for an alternative to frown line treatments like Botox® Cosmetic, Dysport® or Xeomin® and want something that works
fast, lasts, and gives a better look,* experience the DAXXIFY® Difference.

DAXXIFY results

Have an event coming up?

DAXXIFY® kicks in quickly. You may see results as early as the next day after treatment, and typically within 2 days.

Have a busy schedule?

DAXXIFY® is long lasting and keeps frown lines smoother with the convenience of as few as 2 treatments a year. DAXXIFY® results slowly soften over a prolonged period of time*

The DAXXIFY®Look

A better look to skin texture after treatment, smoothing even the deepest lines.

Jeuveau

Jeuveau is one of the more recent members of the neurotoxin family, having gotten the green light from the FDA in February 2019. It is structurally similar to Botox and can treat moderate to severe glabellar lines.

WHAT EXACTLY IS JEUVEAU?

You know those pesky little wrinkles between your eyebrows that won’t go away? Well, they're called glabellar lines, also referred to as "frown lines" or "elevens." Jeuveau is a prescription injectable treatment that works to temporarily improve the appearance of moderate to severe frown lines in adults.

HOW DOES JEUVEAU WORK?

When injected, Jeuveau temporarily prevents your nerves from telling your facial muscles to flex. The result? In clinical trials, Jeuveau was shown to temporarily improve the appearance of moderate to severe frown lines.

WHAT ARE THE RESULTS WITH JEUVEAU?

In clinical trials, Jeuveau was shown to temporarily improve the appearance of moderate to severe frown lines. In US studies, 68% and 70% of Jeuveau patients had a 2-grade or better physician- and patient-rated improvement in frown lines at Day 30. But that's not all. In a study conducted in Europe and Canada, 54% of patients had visible results as early as 2 days after treatment.* And at 5 months after treatment, 38% of patients had visible results with Jeuveau**

*54% of Jeuveau patients had a ≥1-grade improvement in frown lines at Day 2 based on physician assessment compared to 12% for placebo (secondary endpoint). In US studies, 46% and 56% had a ≥1-grade improvement in frown lines at Day 2 based on physician assessment compared to 8% and 17% for placebo (exploratory endpoint). Results based on a 1-grade improvement may not be clinically meaningful.

*38% of Jeuveau patients had a ≥1-grade improvement in frown lines at 5 months based on physician assessment compared to 8% for placebo (secondary endpoint). In US studies, almost 5% of patients had a ≥2-grade improvement in frown lines at 5 months based on both patient and physician assessments compared to 0% for placebo (secondary endpoint). Results after day 30 or based on a 1-grade improvement may not be clinically meaningful.

How Do Neurotoxin Injections Work?

Once a Botulinum toxin product is injected, it stops neural signals that travel from the nerves to the muscles. Left without the instruction to move, the muscles relax, and the skin covering them softens and smooths out. After a few days, you will notice that your lines have become dramatically less visible.

It is important to emphasize that neurotoxins only work on wrinkles created by repeated muscle movements, so-called dynamic wrinkles. They don’t have any effect on wrinkles caused by sun damage or gravity (static wrinkles).

Neurotoxon Injection Procedure

All Botulinum toxin products used for treating wrinkles and fine lines are injected in a quick and relatively painless procedure. The number of units varies depending on the skin condition, the chosen treatment area, and the desired effect.

Neurotoxin injections are administered by an authorized medical professional. You won’t need anesthesia, but your provider may apply a numbing cream to numb the treated area. They will then inject the neurotoxin. There may be some slight discomfort or pressure from the injections but overall the injections are usually well-tolerated.

The treatment typically lasts 15 to 30 minutes. There is no downtime for the neurotoxin injection procedure, so you can resume your normal daily activities.

Your medical professional may advise you to “exercise” your facial muscles gently to even out the absorption of the toxin. Try to avoid profuse sweating the day of your injections and facial massage is not recommended for 10-14 days after your injections.

Neurotoxon Injection Results

The results of all the neurotoxins are temporary. Over time, the injected neurotoxin wears off, and the muscles go back to their regular communication with the nerves. This means that the wrinkles and lines gradually reappear.

If you continue injecting every several months, your muscles may get used to being inactive, so the wrinkles become less pronounced.

· Botox – You can expect to see first results within 72 hours, with full results visible after 14 days. The effects of Botox typically last two to three months.

· Jeuveau – Jeuveau becomes fully visible within three to five days after the procedure and typically lasts around two to three months.

· Daxxify – This neurotoxin is the most durable, lasting three to four months with proper aftercare.

All the neurotoxin injections listed provide dramatic yet natural-looking results. If you are looking to smooth out premature wrinkles and achieve a more youthful look, one of these botulinum toxin solutions can come to the rescue.